翻訳と辞書 Words near each other ・ Death Is Now My Neighbour (TV) ・ Death Is Silent ・ Death Is the Answer ・ Death Is the Only Answer ・ Death Is the Only Mortal ・ Death Dealer II ・ Death Dealers (album) ・ Death Defying ・ Death Defying Acts ・ Death Delights ・ Death Dimension ・ Death Disco ・ Death discography ・ Death Dispatch ・ Death Do Us Part ・ Death domain ・ Death Domain database ・ Death Domination ・ Death drive ・ Death Drive (album) ・ Death Drives Through ・ Death Drug ・ Death Drums Along the River ・ Death du Jour ・ Death Duel ・ Death Duel (video game) ・ Death Duel of Kung Fu ・ Death during consensual sex ・ Death Eater ・ Death education Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Death domain ： ウィキペディア英語版 Death domain The death domain (DD) is a protein interaction module composed of a bundle of six alpha-helices. DD is a subclass of protein motif known as the death fold and is related in sequence and structure to the death effector domain (DED) and the caspase recruitment domain (CARD), which work in similar pathways and show similar interaction properties. DD bind each other forming oligomers. Mammals have numerous and diverse DD-containing proteins. Within these proteins, the DD domains can be found in combination with other domains, including: CARDs, DEDs, ankyrin repeats, caspase-like folds, kinase domains, leucine zippers, leucine-rich repeats (LRR), TIR domains, and ZU5 domains. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB, which typically involves interactions with TNF (tumour necrosis factor) cytokine receptors. In humans, eight of the over 30 known TNF receptors contain DD in their cytoplasmic tails; several of these TNF receptors use caspase activation as a signaling mechanism. The DD mediates self-association of these receptors, thus giving the signal to downstream events that lead to apoptosis. Other DD-containing proteins, such as ankyrin, MyD88 and pelle, are probably not directly involved in cell death signalling. DD-containing proteins also have links to innate immunity, communicating with Toll-like receptors through bipartite adapter proteins such as MyD88. ==See also== * Death Domain database 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Death domain」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.